Biotin is a water-soluble B vitamin that is an essential co-factor for a number of metabolic carboxylation reactions, including carbohydrate, fat and protein metabolism. Biotin provides potential support for healthy glucose metabolism, nerve function and nail strength.

Nutrient Metabolism

Biotin forms a covalent bond to the following carboxylase enzymes: pyruvate carboxylase for glucose metabolism, acetyl CoA carboxylase for fatty acid oxidation, and propionyl-CoA carboxylase and b-methylcrotonyl-CoA carboxylase for amino acid metabolism. One double-blind study reported that biotin supplementation may promote healthy lipid metabolism. Another clinical study reported that high-dose administration of biotin helped promote healthy glucose metabolism. A number of animal studies support this claim. Biotin may also act to promote transcription and translation of glucokinase, an enzyme found in the liver and pancreas that participates in the metabolism of glucose to form glycogen. Recent studies have expanded biotin’s metabolic role, claiming that the vitamin maintains healthy genetic expression of the many enzymes for which it is a cofactor. One study suggested that this gene modulation is supportive of healthy immune system function, stating that biotin may be involved in the transcription of some immune cells.

Nerve Function

Optimal levels of biotin are supportive of nervous system health and function. A clinical study indicated that biotin promotes nerve cell health.

Nail Health

Clinical studies indicate that biotin may adjust the cellular arrangement of the nail bed, helping to reinforce the keratin structure, promote strength and thickness, and reduce splitting.



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