Acetyl-L-Carnitine plays a key role in maintaining normal brain and nerve function during aging, as many well-designed human and animal studies have shown consistently. Acetyl-L-Carnitine is a naturally occurring metabolite of L carnitine, and both are present in the diet, particularly in foods of animal origin. In most tissues of the body, both L-carnitine and acetyl-L carnitine are involved in fatty acid oxidation. They are part of the so-called carnitine shuttle. L-carnitine shuttles fatty acids from the cytosol (the cell fluid) into the mitochondria (the cell’s powerhouses) for oxidation and energy production. The main end products of fatty acid oxidation are energy (in the form of NADH), and acetyl groups. Most of these acetyl groups are further oxidized in the mitochondria’s Krebs cycle, but some are needed in the cytosol for producing other important metabolites. Acetyl-L-carnitine provides a way to carry these acetyl groups through the mitochondrial membranes back out into the cytosol.



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